NARep AI: Drug Repurposing Engine

Computational analysis identifying novel therapeutic applications for FDA-approved compounds in CNS and psychiatric indications. Free for non-commercial research.

Therapeutic Areas: Treatment-resistant psychiatric disorders • Neurodegenerative diseases • Substance use disorders • Pediatric CNS conditions • Rare neurological diseases

Submit Your Research Query

Structure your query to include: indication, patient population, mechanism preferences, contraindications, and trial parameters.

Example: "Identify off-patent repurposing candidates for treatment-resistant social anxiety disorder in adults. Requirements: SSRI-compatible, rapid onset (<2 weeks), low abuse potential, CNS penetration data, non-GABA/serotonin mechanisms. Include biomarkers for 8-week POC trial."

Tips for optimal results:

  • Specify if you need off-patent drugs only

  • Include patient population details (age, comorbidities)

  • List current standard treatments to ensure compatibility

  • Mention specific mechanisms to explore or avoid

  • Add practical constraints (onset time, safety requirements)

  • Request biomarkers if planning trials

Research Analysis Request Form

By submitting this form, you confirm this is for non-commercial research purposes. We typically respond within 1-3 business days with the AI’s analysis as a deliverable sent to the provided email address. Your data is confidential.

Deliverable: Mechanistic analysis of repurposing candidates including CNS penetration data, drug-drug interactions, clinical evidence synthesis, biomarker recommendations, and regulatory pathway assessment.

Support Our Mission

As a nonprofit, we rely on donations to maintain and improve our AI platform. If our analysis helps advance your research, please consider making a donation to ensure continued free access for the research community.

Suggested donation levels:

  • Student/Postdoc: $25-50

  • Research Grant Funded: $100-250

  • Institution/Department: $500+

Every contribution helps us provide free analyses to researchers worldwide.

Questions?

Email us at info@nourishappalachia.org

For commercial partnerships and licensing opportunities, please visit our Drug Repurposing Services page.

All analyses support Nourish Appalachia's mission of advancing accessible psychiatric and CNS treatments for underserved communities in Appalachia.